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Research highlights of the Laboratory of Evidence-Based Molecular Epidemiology (LEBME)
Dr. Wang worked with doctors from various departments; for example, he studied with gastrointestinal doctors to conduct a systematic review and meta-analysis to evaluate the risk of post-operative complications associated with pre-operative exposure to anti-tumour necrosis factor agents for Crohn’s disease. Recently, Dr. Wang interested in the field of integrating real-world data such as National Health Insurance Research Database and Taipei Medical University Clinical Research Database, combined with the biospecimen collected from Taipei Medical University-Joint Biobank for identifying useful biomarkers to establish a disease-specific risk prediction model. In the further works, the innovative, translational and evidence-based medical research has ever been a pursuit in his academic research career.
Email | d508091002@tmu.edu.tw
Profile | Academic Hub/Pure Experts
Yuan-Hung Wang
Yuan-Hung Wang
Graduate Institute of Clinical Medicine
Associate Professor (Ph.D.)
Research Interests
Molecular Epidemiology, Precision Medicine, Evidence-Based Medicine, Oncology, Urothelial Carcinoma
Laboratory
Laboratory of Evidence-Based Molecular Epidemiology (LEBME)
Dr. Wang started his master’s course in 1997 and occupied a Research Assistant at the Institute of epidemiology at the National Taiwan University up to 2002.
1993 – 2005
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2007 – After
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Currently, Dr. Wang is an Associate Professor at the Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan, and worked at the Department of Medical Research, Shuang Ho Hospital, Taipei Medical University as a senior research fellow. Over the last 10 years, he has focused his scientific interests on the topics related to chronic diseases including bladder cancer, prostate cancer and colorectal cancer, and cardiovascular diseases. With his expertise in Public Health, Molecular Epidemiology and Evidence-Based Medicine, he has established a series of platforms for preclinical evaluation of diagnostics/therapeutics. In addition, Dr. Wang has published numerous SCI journal papers and reviewed for many academic journals.
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01
Chia-Chang Wu
M.D. , Ph.D. (Collaborator)
02
Yu-Ting Wang
M.D. (MS Student)
03
Yang-Hsiu Sun
O.T. (MS Student)
04
Wen-Shan Wei
R.N. (MS Student)
05
Yu-Feng Wang
Pharmacist (MS Student)
06
Tsai-Hsuan Wang
Medical Technologist (MS Student)
07
Ching-Lan Huang
Special Education Teacher (MS Student)
08
Yu-Ting Hsu
B.S. (Research Assistant)
09
Cheng-Chieh Chen
Medical Technologist (Collaborator)
2022
Chen CC, Hsiao KY, Bai CH, Wang YH*.
Investigation of the diagnostic performance of the SARS-CoV-2 saliva antigen test: A meta-analysis. J Microbiol Immunol Infect.
2022 Dec;55(6 Pt 1):1084-1093.
Abstract
Background: The COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Rapid identification and isolation of patients with COVID-19 are critical strategies to contain COVID-19. The saliva antigen test has the advantages of noninvasiveness and decreased transmission risk to health-care professionals. This meta-analysis investigated the diagnostic accuracy of the saliva antigen test for SARS-CoV-2. Methods: We searched for relevant studies in PubMed, Embase, Cochrane Library, and Biomed Central. Studies evaluating the diagnostic accuracy of saliva antigen tests for SARS-CoV-2 were included. The data of the included studies were used to construct a 2 × 2 table on a per patient basis. The overall sensitivity and specificity of saliva antigen tests were determined using a bivariate random-effects model. Results: Nine studies enrolling 9842 patients were included. The meta-analysis generated a pooled sensitivity of 65.3% and a pooled specificity of 99.7%. A subgroup analysis of the studies performing the chemiluminescent enzyme immunoassay (CLEIA) for participants from airports and public health centers revealed a pooled sensitivity of 93.6%. Conclusion: Our findings demonstrated that the saliva antigen test performed using CLEIA exhibited higher sensitivity for the detection of SARS-CoV-2. Therefore, the saliva antigen test performed using CLEIA might be an effective and noninvasive screening tool for SARS-CoV-2.
Liu WT*, Wang YH*, Chang LT, Wu CD, Wu D, Tsai CY, Lo CC, Lo K, Chung KF, Chang TY, Chuang KJ, Lee YL, Chuang HC.
The impacts of ambient relative humidity and temperature on supine position-related obstructive sleep apnea in adults.Environ Sci Pollut Res Int.
2022 Jul;29(33):50755-50764. (*equal first author)
Abstract
Obstructive sleep apnea (OSA) is associated with seasonal variations. The objective of this study was to examine associations of ambient relative humidity (RH) and temperature on sleep parameters. We conducted a cross-sectional study by retrospectively recruiting 5204 adults from a sleep center in Taipei, Taiwan. Associations of 1-night polysomnography with ambient RH and temperature in 1-day, 7-day, 1-month, 6-month, and 1-year averages were examined using linear regression models and a mediation analysis. RH increase was associated with snoring index decrease and apnea/hypopnea index (AHI) increase. Temperature increase was associated with decreases in sleep efficiency and the AHI, and increases in the wake time after sleep onset and snoring index. RH increase was inversely associated with non-rapid eye movement (NREM) sleep stage I (N1), III (N3), and rapid eye movement (REM) sleep, but positively associated with the NREM sleep stage II (N2) stage. Temperature increase was associated with N1, N2, and N3 sleep. An increase in RH was associated with an increase in the arousal index and a decrease in the < 95% arterial oxygen saturation (SaO2) among total, REM, and NREM sleep, whereas a temperature increase was associated with a decrease in the arousal index and an increase in＜95% SaO2 among total, REM, and NREM sleep. An increase in RH was associated with increases in the time spent in a supine posture and the supine AHI. An increase in temperature was associated with decreases in the supine posture, supine AHI, and non-supine AHI. The N3 sleep stage was an important mediator in increasing the supine AHI with a long-term increase in RH. But the N1 and N2 sleep stages mediated a decrease in the supine AHI with an increase in RH. In conclusion, ambient RH and temperature were associated with alterations in sleep parameters in adults, which were mediated by the sleep cycle. An understanding of outdoor environments has important implications for diagnostic classifications in the supine dominance of OSA in adults.
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Huang YH, Chiu WC, Hsu YP, Lo YL, Wang YH*.
Effects of Omega-3 Fatty Acids on Muscle Mass, Muscle Strength and Muscle Performance among the Elderly: A Meta-Analysis. Nutrients.
2020 Dec 4;12(12):3739.
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Abstract
There is increasing evidence showing the role of fatty acids and their derived lipid intermediates in the regulation of skeletal muscle mass synthesis and function. However, the role of omega-3 fatty acids remains unclear. Therefore, we conducted a meta-analysis to evaluate the potential effects of omega-3 fatty acids on sarcopenia-related performances among the elderly. Eligible literature and reports of randomized controlled trials were comprehensively searched from the PubMed, Cochrane Library, ClinicalTrials.gov, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases until July 2018. A total of 10 articles were available for the meta-analysis. There were minor benefits for muscle mass gain (0.33 kg; 95% CI: 0.05, 0.62) and timed up and go performance (−0.30 s; 95% CI: −0.43, −0.17). Subgroup analyses regarding muscle mass and walk speed indicated that omega-3 fatty acid supplements at more than 2 g/day may contribute to muscle mass gain (0.67 kg; 95% CI: 0.16, 1.18) and improve walking speed, especially for those receiving more than 6 months of intervention (1.78 m/sec; 95% CI: 1.38, 2.17). Our findings provide some insight into the effects of omega-3 fatty acids on muscle mass, especially for those taking supplements at more than 2 g/day. We also observed that a long period of omega-3 fatty acids supplementation may improve walking speed.
Chiu YF, Wu CC, Kuo MH, Miao CC, Zheng MY, Chen PY, Lin SC, Chang JL, Wang YH*, Chou YT*.
Critical role of SOX2-IGF2 signaling in aggressiveness of bladder cancer. Sci Rep.
2020 May 19;10(1):8261. (*equal corresponding author)
Abstract
Signaling elicited by the stem cell factors SOX2, OCT4, KLF4, and MYC not only mediates reprogramming of differentiated cells to pluripotency but has also been correlated with tumor malignancy. In this study, we found SOX2 expression signifies poor recurrence-free survival and correlates with advanced pathological grade in bladder cancer. SOX2 silencing attenuated bladder cancer cell growth, while its expression promoted cancer cell survival and proliferation. Under low-serum stress, SOX2 expression promoted AKT phosphorylation and bladder cancer cells’ spheroid-forming capability. Furthermore, pharmacological inhibition of AKT phosphorylation, using MK2206, inhibited the SOX2-mediated spheroid formation of bladder cancer cells. Gene expression profiling showed that SOX2 expression, in turn, induced IGF2 expression, while SOX2 silencing inhibited IGF2 expression. Moreover, knocking down IGF2 and IGF1R diminished bladder cancer cell growth. Lastly, pharmacological inhibition of IGF1R, using linsitinib, also inhibited the SOX2-mediated spheroid formation of bladder cancer cells under low-serum stress. Our findings indicate the SOX2–IGF2 signaling affects the aggressiveness of bladder cancer cell growth. This signaling could be a promising biomarker and therapeutic target for bladder cancer intervention.
2019
Lin YS, Cheng SW, Wang YH*, Chen KH, Fang CJ, Chen C*.
Systematic review with meta-analysis: risk of post-operative complications associated with pre-operative exposure to anti-tumour necrosis factor agents for Crohn’s disease. Aliment Pharmacol Ther.
2019 Apr;49(8):966-977. (*equal corresponding author)
Abstract
Background: Post-operative complications after anti-tumour necrosis agent treatment for Crohn’s disease (CD) have been analysed with conflicting results. Aim: To assess the effects of pre-operative anti-tumour necrosis factor (TNF) therapy on post-operative complications within 30 days post-operatively in patients with CD undergoing abdominal surgery. Methods: Systematic review with meta-analysis was performed on articles found in MEDLINE, Embase, Cochrane Library, Scopus, and the International Clinical Trials Registry Platform until September 2018. Results: Twenty studies (7115 patients) were included. Without confounder adjustment, pre-operative anti-TNF therapy in patients with CD undergoing abdominal surgery was associated with increased rates of infectious complications (unadjusted odds ratio, OR, 1.49; 95% CI, 1.08-2.06). After confounder adjustment, Pre-operative anti-TNF therapy was significantly associated with both increased rates of total and infectious complications (adjusted OR, 1.53 and 2.09; 95% CI, 1.11-2.09 and 1.19-3.65, respectively). After subgroup analyses, the association between anti-TNF agents and total complications was significant in high incidence countries (adjusted OR, 1.86; 95% CI, 1.43-2.42) but not in low incidence countries (adjusted OR, 0.77; 95% CI, 0.48-1.25). Conclusions: Exposure to anti-TNF agents is an independent risk factor for post-operative infectious complications in patients with CD, especially in countries with a high incidence of Crohn’s disease. We suggest postponing elective surgery or carefully monitoring these patients post-operatively.
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