Research | Departments
Research
Departments
Research | Departments
Research
Departments
Our research is dedicated to unraveling the intricate mechanisms of cardiac fibrogenesis and the pathophysiology of heart failure. We focus on critical aspects, including epigenetic regulation, cardiac metabolism, and mitochondrial function. By adopting a comprehensive approach, we aim to contribute insights that extend beyond cardiac research, advancing our understanding of broader medical challenges.
Our investigations bridge the gap between molecular mechanisms, calcium signaling, and fibroblast behavior in heart failure and fibrogenesis. These findings hold promise for future therapeutic strategies in cardiovascular medicine and may provide valuable insights for developing targeted therapies in heart failure management.
Email | yuhsunkao@tmu.edu.tw
Profile | Academic Hub/Pure Experts
Associate Professor (Ph.D.)
Epigenetic regulation in cardiac pathophysiology
Laboratory of Heart Failure, Cardiac Metabolism and Fibrogenesis
–
–
–
Yu-Hsun Kao received her Ph.D. in the Graduate Institute of Life Sciences, National Defense Medical Center in 2008. She has been a postdoctoral fellow for four years at Taipei Medical University (TMU). In 2013, she was employed as an Assistant Professor at TMU. Dr. Kao is an Associate Professor at the Graduate Institute of Clinical Medicine, College of Medicine, TMU in 2016. Her research topics include cellular metabolism, calcium homeostasis, and epigenetic regulation in cardiac pathophysiology.
–
(Associate Professor)
(Ph.D student)
(Ph.D student)
(Ph.D student)
Huynh TV, Rethi L, Lee TW, Higa S, Kao YH*, Chen YJ.
Spike Protein Impairs Mitochondrial Function in Human Cardiomyocytes: Mechanisms Underlying Cardiac Injury in COVID-19. Cells.
2023 Mar 11;12(6):877.
Abstract
–
Kao YH, Chung CC, Cheng WL, Lkhagva B, Chen YJ.
Pitx2c inhibition increases atrial fibroblast activity: Implications in atrial arrhythmogenesis.
Eur J Clin Invest. 2019 Oct;49(10):e13160.
Abstract
–
Lee TW, Lee TI, Lin YK, Kao YH*, Chen YJ*.
Calcitriol downregulates fibroblast growth factor receptor 1 through histone deacetylase activation in HL-1 atrial myocytes.
J Biomed Sci. 2018 May 18;25(1):42
Abstract
–
Lee TW, Bai KJ, Lee TI, Chao TF, Kao YH*, Chen YJ.
PPARs modulate cardiac metabolism and mitochondrial function in diabetes.
J Biomed Sci. 2017 Jan 10;24(1):5.
Abstract
–
Kao YH, Chen YC, Cheng CC, Lee TI, Chen YJ, Chen SA.
Tumor necrosis factor-alpha decreases sarcoplasmic reticulum Ca2+-ATPase expressions via the promoter methylation in cardiomyocytes.
Crit Care Med. 2010 Jan;38(1):217-22.
Abstract
–