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Research highlights of the Laboratory of tissue injury and repair
The interests of our lab are mainly focused on the pathogenesis of kidney, liver, and thyroid diseases, especially inflammation-related tissue injury and repairment in animal models. Based on our findings, we aimed to develop potential therapeutic regimens and disease injury markers for the management.
Email | ccheng@tmu.edu.tw
Profile | Academic Hub/Pure Experts
Chao-Wen Cheng
Chao-Wen Cheng
Graduate Institute of Clinical Medicine
Professor (Ph.D)
Research Interests
Immunopathology, Molecular Pathology
Laboratory
Laboratory of tissue injury and repair
Prof. Cheng received his Ph.D. degree in 2005 from the Graduate Institute of Life Sciences, National Defense Medical Center in Taiwan. After military service, he joined the Liver Research Center at Rhode Island Hospital (Brown University) in 2007 and completed his postdoctoral training in 2009. In the postdoctoral fellowship, he focused on understanding the role of NKT (Gastroenterology, 2009), and NK cells (Journal of Hepatology, 2011) in cholestatic liver injury. Thereafter, Prof. Cheng was employed as an assistant professor in 2010 and became a Full Professor in 2020 at the Graduate Institute of Clinical Medicine, Taipei Medical University.
1993 – 2005
Dr. Tsai graduated with an M.D. from Taipei Medical University (Taiwan) in 1993, and completed his clinical training in internal medicine, gastroenterology, and GI oncology. Dr. Tsai then earned his Ph.D. in Biological Sciences – Genetics and Complex Diseases from Graduate School of Arts and Sciences, Harvard University (MA, USA) in 2005. During his thesis work, Dr. Tsai established novel 3D coculture models to interrogate stress-induced stromal-epithelial interactions.
2007 – After
In 2007, he conducted postdoctoral research at the University of Pennsylvania (PA, USA) and the University of California San Francisco (CA, USA) and spearheaded the study of novel tissue-architecture-related mechanisms of multi-drug resistance in cancer. Following his postdoc research, Dr. Tsai joined the National Institute of Cancer Research in National Health Research Institutes (NHRIs) as an Investigator, and then became the Director and Professor of Graduate Institute of Clinical Medicine at Taipei Medical University.
Dr. Tsai is the recipient of many awards, including Harvard Presidential Scholar, USA, Outstanding Research Award, Taiwan, Kobayashi’s Foundation Award, Japan, and Young Scientists Research Achievement Award of NHRIs, Taiwan. He is the first or corresponding author of more than 30 research papers in top-notch biomedical journals such as Nature Cancer, Gastroenterology, J Exp Med, J Am Coll Cardiol, Gut, Cancer Res, etc, and he also served as the PI in several GI cancer-related clinical trials.
His major scientific achievements include the identification of a regulatory hub of developmental/stemness signaling and invadopodia that drives cancer stemness and progression, which may hold promises for development into novel CSC-targeted therapies. He co-identified a cell-intrinsic and chromatin-mediated cellular “death checkpoint” whereby most malignant tumors resist cytotoxic stress; the targeting of which yields an exciting opportunity for sensitizing malignant tumors to chemotherapy and immunotherapy.
01
Su-Wei Hu
Ph.D Student
02
Thokozani Sawasawa
Ph.D Student
03
Yea-Mey Yang
Research Assistant
2022
Cheng CW, Fang WF, Tang KT, Lin JD.
The pathogenic role of IFN-α in thyroiditis mouse models.
Life Sci. 2022 Jan 1;288:120172.
Abstract
–
Hu SW, Wang YH, Huang JS, Yang YM, Wu CC, Cheng CW.
The PDE5 inhibitor, vardenafil, ameliorates progressive pathological changes in a focal segmental glomerulosclerosis mouse model.
Life Sci. 2022 Nov 15;309:120992
Abstract
–
2021
Cheng CW, Duwaerts CC, Rooijen Nv, Wintermeyer P, Mott S, Gregory SH.
NK cells suppress experimental cholestatic liver injury by an interleukin-6-mediated, Kupffer cell-dependent mechanism.
J Hepatol. 2011 Apr;54(4):746-52.
2009
Wintermeyer P, Cheng CW, Gehring S, Hoffman BL, Holub M, Brossay L, Gregory SH.
Invariant natural killer T cells suppress the neutrophil inflammatory response in a mouse model of cholestatic liver damage. Gastroenterology.
2009 Mar;136(3):1048-59.
2005
Cheng CW, Rifai A, Ka SM, Shui HA, Lin YF, Lee WH, Chen A.
Calcium-binding proteins annexin A2 and S100A6 are sensors of tubular injury and recovery in acute renal failure.
Kidney Int. 2005 Dec;68(6):2694-703.
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