Atrial fibrillation is a common cardiac arrhythmia seen in clinical practice. It can lead to impaired heart function and stroke. I have dedicated my research to exploring the pathophysiological mechanisms of atrial fibrillation. As the first scholar in the world, I successfully isolated atrial myocytes from the pulmonary veins and superior vena cava for electrophysiological studies, which were published in important cardiovascular journals (Circulation 2001; Circulation 2002; JACC 2002; Cardiovasc Res 2000). Additionally, my laboratory discovered electrophysiological differences between left atrial anterior and posterior wall myocytes. These studies not only enhanced our understanding of cardiac myocyte electrophysiology globally but also provided essential insights for antiarrhythmic drug research in atrial fibrillation.

Our research findings have had a decisive impact on the cellular pathophysiology of atrial fibrillation triggered by the pulmonary veins. I have been invited to present at numerous domestic and international conferences and have shared my results with the scientific community. The Ministry of Science and Technology has recognized my contributions through the Young Scholar Research Program and the Outstanding Scholar Development Program. I was honored with the 2012 Ding-Nung Award from the Taiwan Society of Cardiology.

Furthermore, my laboratory made a groundbreaking discovery regarding the role of epigenetic regulation in calcium ion homeostasis. Additionally, our investigations into cellular calcium ion regulation could potentially lead to novel treatments for arrhythmias and heart failure We have also explored the roles of fibrosis and adipocytes in arrhythmias and heart failure (Basic Res Cardiol 2012, Int J Cardiol 2013, 2014, Acta Physiologica 2017, J Mol Cell Cardiol 2018, Lab Invest 2019). These translational studies provide crucial medical insights.”