Our laboratory is interested in identifying new biomarkers using public databases, such as The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), for predicting the effectiveness of anti-cancer therapies, e.g. radiotherpy, chemotherapy and immunotherapy, in different cancer types. We have set up several cell-based assays to examine the irradiation/chemotherapeutic/immunotherapeutic sensitivity and cellularl migration/invasion ability of tested cancer cells. We have also established orthotopic mouse models for brest cancer and oral cancer to evaluate the capacity of identified oncogenic drivers in promoting tumor growth and distant metastasis. Because genetic defects frequently result in the alteration of protein-protein interaction (PPI) network, our laboratory is also interested in discovering drug-targetable PPIs in malignancies by utiziling iodoacetamide-based probes.