【Academic Activities】2022.02.22(W2) 10:00-12:00 - Moon-Shan Biomedical Research Forum
Moon-Shan Biomedical Research Forum
Topic: Chromatin remodeling genes in gynecologic cancer progression and therapy.
Speaker: Ie-Ming Shih, M.D., Ph.D.
Richard W. TeLinde Distinguished Professor
Director, TeLinde Gynecologic Disease Program
Co-Director, Women’s Malignancies Program
School of Medicine, Johns Hopkins University
Date: February 22, 2022, 10:00-12:00
Venue: 4F Hall, United Medical Building
Language: Chinese
Organizer: Graduate Institute of Medical Sciences, TMU
Abstract:
ARID1A has emerged as a tumor suppressor gene, which is mutated in a broad spectrum of cancers, especially in those gynecologic cancers arising from ectopic or eutopic endometrium including ovarian clear cell, ovarian endometrioid and uterine endometrioid carcinomas. As a subunit of SWI/SNF chromatin remodeler, ARID1A facilitates target-specific binding of SWI/SNF complexes to chromatin, thereby altering the accessibility of chromatin to a variety of nuclear factors. In human cancer, ARID1A possesses not only features of a gatekeeper, regulating cell cycle progression, but also features of a caretaker, preventing genomic instability through DNA damage repair. Moreover, an increasing body of evidence suggests that ARID1A containing SWI/SNF complexes play a pivotal role in transcriptional regulation of genes involving in several cancer-associated signaling pathways. In this seminar, we will discuss the mechanisms underlying how ARID1A mutations cause cancer progression and the clinical implications of synthetic lethality in developing ARID1A mutation-based therapeutics.
This course counts toward the continuing education points of faculty members as well as the education training hours required of staff members. https://ehrd.tmu.edu.tw/eHRD/eHRDOrg
For details please send email to Ms Lu: lu99@tmu.edu.tw
Please wear mask when you’re in the 4F Hall and bring Your Own Mug (BYOM). Going green is as easy as bringing your own cup.
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